R. M., Dannemann, M.,
et al., «Excavating Neandertal and Denisovan DNA from the Genomes of Melanesian Individuals»,
Science, 352, 6282 (2016), p. 235–239.
Vicente, M., Priehodova, E., Diallo, I., Podgorna, E., Poloni, E. S., Cerny, V., Schlebusch, C. M., «Population History and Genetic Adaptation of the Fulani Nomads: Inferences from Genome-Wide Data and the Lactase Persistence Trait», BMC Genomics, 20, 1 (2019), p. 915.
Webster, T. H., Wilson Sayres, M. A., «Genomic Signatures of Sex-Biased Demography: Progress and Prospects», Curr. Opin. Genet. Dev., 41 (2016), p. 62–71.
Wen, B., Li, H., Lu, D., Song, X., Zhang, F., He, Y., Li, F., et al., «Genetic Evidence Supports Demic Diffusion of Han Culture», Nature, 431, 7006 (2004), p. 302–305.
Zeberg, H., Paabo, S., «A Genomic Region Associated with Protection against Severe COVID-19 Is Inherited from Neandertals», Proc. Natl Acad. Sci. USA, 118, 9 (2021), e2026309118.
Zeberg, H., Paabo, S., «The Major Genetic Risk Factor for Severe COVID-19 Is Inherited from Neanderthals», Nature, 587, 7835 (2020), p. 610–612.
Zhang, Q., Bastard, P., Liu, Z., Le Pen, J., Moncada-Velez, M., Chen, J., Ogishi, M., et al., «Inborn Errors of Type I Ifn Immunity in Patients with Life-Threatening COVID-19», Science, 370, 6515 (2020).
Zhernakova, A., Elbers, C. C., Ferwerda, B., Romanos, J., Trynka, G., Dubois, P. C., de Kovel, C. G., et al., «Evolutionary and Functional Analysis of Celiac Risk Loci Reveals Sh2b3 as a Protective Factor against Bacterial Infection», Am. J. Hum. Genet., 86, 6 (2010), p. 970–777.
Zhou, Q., Zhao, L., Guan, Y., «Strong Selection at Mhc in Mexicans since Admixture», PLoS Genet., 12, 2 (2016), e1005847.
Эпилог
Adhikari, K., Chacon-Duque, J. C., Mendoza-Revilla, J., Fuentes-Guajardo, M., Ruiz-Linares, A., «The Genetic Diversity of the Americas», Annu. Rev. Genomics Hum. Genet., 18 (2017), p. 277–296.
Amariuta, T., Ishigaki, K., Sugishita, H., Ohta, T., Koido, M., Dey, K. K., Matsuda, K., et al., «Improving the Trans-Ancestry Portability of Polygenic Risk Scores by Prioritizing Variants in Predicted Cell-Type-Specific Regulatory Elements», Nat. Genet., 52, 12 (2020), p. 1346–1354.
Boyle, E. A., Li, Y. I., Pritchard, J. K., «An Expanded View of Complex Traits: From Polygenic to Omnigenic», Cell, 169, 7 (2017), p. 1177–1186.
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L. T., Sharp, K., Motyer, A., et al., «The Uk Biobank Resource with Deep Phenotyping and Genomic Data», Nature, 562, 7726 (2018), p. 203–209.
Cairns, J., Matters of Life and Death, Princeton, Princeton University Press, 1997.
Casanova, J. L., Abel, L., «Inborn Errors of Immunity to Infection: The Rule Rather Than the Exception», J. Exp. Med., 202, 2 (2005), p. 197–201.
Fan, S., Hansen, M. E., Lo, Y., Tishkoff, S. A., «Going Global by Adapting Local: A Review of Recent Human Adaptation», Science, 354, 6308 (2016), p. 54–59.
Ge, D., Fellay, J., Thompson, A. J., Simon, J. S., Shianna, K. V., Urban, T. J., Heinzen, E. L., et al., «Genetic Variation in Il28b Predicts Hepatitis C Treatment-Induced Viral Clearance», Nature, 461, 7262 (2009), p. 399–401.
Kerner, G., Patin, E., Quintana-Murci, L., «New Insights into Human Immunity from Ancient Genomics», Curr. Opin. Immunol., 72 (2021), p. 116–125.
Krausz, C., Quintana-Murci, L., Rajpert-De Meyts, E., Jorgensen, N., Jobling, M. A., Rosser, Z. H., Skakkebaek, N. E., McElreavey, K., «Identification of a Y Chromosome Haplogroup Associated with Reduced Sperm Counts», Hum. Mol. Genet., 10, 18 (2001), p. 1873–1877.
Martin, A. R., Gignoux, C. R., Walters, R. K., Wojcik, G. L., Neale, B. M., Gravel, S., Daly, M. J., Bustamante, C. D., Kenny, E. E., «Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations», Am. J. Hum. Genet., 100, 4 (2017), p. 635–649.
Martin, A. R., Kanai, M., Kamatani, Y., Okada, Y., Neale, B. M., Daly, M. J., «Clinical Use of Current Polygenic Risk Scores May Exacerbate Health Disparities», Nat. Genet., 51, 4 (2019), p. 584–591.
Mostafavi, H., Berisa, T., Day, F. R., Perry, J. R. B., Przeworski, M., Pickrell, J. K., «Identifying Genetic Variants That Affect Viability in Large Cohorts», PLoS Biol., 15, 9 (2017), e2002458.
Ochi, H., Maekawa, T., Abe, H., Hayashida, Y., Nakano, R., Imamura, M., Hiraga, N., et al., «Il-28b Predicts Response to Chronic Hepatitis C Therapy – Fine-Mapping and Replication Study in Asian Populations», J. Gen. Virol., 92, Pt 5 (2011), p. 1071–1081.
Pizzol, D., Foresta, C., Garolla, A., Demurtas, J., Trott, M., Bertoldo, A., Smith, L., «Pollutants and Sperm Quality: A Systematic Review and Meta-Analysis», Environ. Sci. Pollut. Res. Int., 28, 4 (2021), p. 4095–40103.
Quintana-Murci, L., «Human Immunology through the Lens of Evolutionary Genetics», Cell, 177, 1 (2019), p. 184–199.
Sirugo, G., Williams, S. M., Tishkoff, S. A., «The Missing Diversity in Human Genetic Studies», Cell, 177, 4 (2019), p. 1080.
Thomas, D. L., Thio, C. L., Martin, M. P., Qi, Y., Ge, D., O’Huigin, C., Kidd, J., et al., «Genetic Variation in Il28b and Spontaneous Clearance of Hepatitis C Virus», Nature, 461, 7265 (2009), p. 798–801.
Thomas, S., Rouilly, V., Patin, E., Alanio, C., Dubois, A., Delval, C., Marquier, L. G., et al., «The Milieu Interieur Study – An Integrative Approach for Study of Human Immunological Variance», Clinical Immunology, 157, 2 (2015), p. 277–293.
Torkamani, A., Wineinger, N. E., Topol, E. J., «The Personal and Clinical Utility of Polygenic Risk Scores», Nat. Rev. Genet., 19, 9 (2018), p. 581–590.
Zeberg, H., Paabo, S., «A Genomic Region Associated with Protection against Severe COVID-19 Is Inherited from Neandertals», Proc. Natl Acad. Sci. USA, 118, 9 (2021), e2026309118.
Zeberg, H., Paabo, S., «The Major Genetic Risk Factor for Severe COVID-19 Is Inherited from Neanderthals», Nature, 587, 7835 (2020), p. 610–612.
Примечания
1
Феодосий Григорьевич Добржанский (англ. Theodosius Dobzhansky; 12 [24] января 1900, Немиров, Подольская губерния – 18 декабря 1975, Сан-Джасинто, Калифорния, США) – русский и американский генетик, энтомолог, один из основателей синтетической теории эволюции, дальний правнук русского писателя Ф. М. Достоевского (Прим. перев.).
2
Речь о завершении проекта «Геном человека». (Прим. науч. ред.)
3
Анаксимандр
